> HI all,
>
> We know one protein can interact with different partners by different
> domains or different parts. Is there a protein that it could interact
> with different proteins by the same part (maybe the same part but in
> different conformations?)? Thank you in advance!!
>
> yamei
>
>
> From: Petr Kolenko
> What about polyclonal antibody? I am sure that you find some
> structures in the PDB.
>
> Petr
>
> What about polyclonal antibody? I am sure that you find some
> structures in the PDB.
>
> Petr
>
> From: "Brett, Thomas"
> Look at AP-2 alpha-appendage. And for that matter, the beta appendage too. Alpha appendage binds ~30 different proteins using two sites on one domain.
>
> J Biol Chem. 2004 Oct 29;279(44):46191-203. Epub 2004 Aug 2.
> Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage.
> Mishra SK, Hawryluk MJ, Brett TJ, Keyel PA, Dupin AL, Jha A, Heuser JE, Fremont DH, Traub LM.
>
> Structure. 2002 Jun;10(6):797-809.
> Accessory protein recruitment motifs in clathrin-mediated endocytosis.
> Brett TJ, Traub LM, Fremont DH.
>
>
> Mol Biol Cell. 2008 Dec;19(12):5309-26. Epub 2008 Oct 8.
> The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis.
> Keyel PA, Thieman JR, Roth R, Erkan E, Everett ET, Watkins SC, Heuser JE, Traub LM.
>
> -Tom
> Tom J. Brett, PhD
> Assistant Professor of Medicine
> Division of Pulmonary and Critical Care
> Washington University School of Medicine
> Campus Box 8052, 660 S. Euclid
> Saint Louis, MO 63110
_______________________________________
Radisky, Evette S., Ph.D.
> This is very common among the small GTP-binding proteins of the Ras
> superfamily. For an interesting analysis (although doubtless there are
> lots of more recent examples) you might look at:
> Corbett and Alber, TIBS 26 (12) 710-716 (2001)
>
> Evette S. Radisky, Ph.D.
> Assistant Professor
> Mayo Clinic Cancer Center
> Griffin Cancer Research Building, Rm 310
> 4500 San Pablo Road
> Jacksonville, FL 32224
> (904) 953-6372
>
> Look at AP-2 alpha-appendage. And for that matter, the beta appendage too. Alpha appendage binds ~30 different proteins using two sites on one domain.
>
> J Biol Chem. 2004 Oct 29;279(44):46191-203. Epub 2004 Aug 2.
> Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage.
> Mishra SK, Hawryluk MJ, Brett TJ, Keyel PA, Dupin AL, Jha A, Heuser JE, Fremont DH, Traub LM.
>
> Structure. 2002 Jun;10(6):797-809.
> Accessory protein recruitment motifs in clathrin-mediated endocytosis.
> Brett TJ, Traub LM, Fremont DH.
>
>
> Mol Biol Cell. 2008 Dec;19(12):5309-26. Epub 2008 Oct 8.
> The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis.
> Keyel PA, Thieman JR, Roth R, Erkan E, Everett ET, Watkins SC, Heuser JE, Traub LM.
>
> -Tom
> Tom J. Brett, PhD
> Assistant Professor of Medicine
> Division of Pulmonary and Critical Care
> Washington University School of Medicine
> Campus Box 8052, 660 S. Euclid
> Saint Louis, MO 63110
_______________________________________
Radisky, Evette S., Ph.D.
> This is very common among the small GTP-binding proteins of the Ras
> superfamily. For an interesting analysis (although doubtless there are
> lots of more recent examples) you might look at:
> Corbett and Alber, TIBS 26 (12) 710-716 (2001)
>
> Evette S. Radisky, Ph.D.
> Assistant Professor
> Mayo Clinic Cancer Center
> Griffin Cancer Research Building, Rm 310
> 4500 San Pablo Road
> Jacksonville, FL 32224
> (904) 953-6372
>
> From: Poul Nissen
> Calmodulin
>
> Poul
> Calmodulin
>
> Poul
> The RNA Polymerase II rpb1 CTD interacts with numerous other proteins - it's disordered in isolation, and adopts different conformations with different binding partners (at least in the available structures).
> From: Ed Pozharski
> Lysozyme interacts with two antibodies, HyHel-5 and D44.1 via the same
> epitope but different set of interactions.
>
> --
> "Hurry up before we all come back to our senses!"
> Julian, King of Lemurs
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