Staff Scientist and Post-doctoral positions in
Structural Biology and Biochemistry/Enzymology
Following the award of a Wellcome Trust Senior Investigator Award to Professor Dale Wigley, the Institute of Cancer Research is seeking to appoint a Staff Scientist and two post-doctoral fellows on a programme to study chromatin modifying complexes involved in DNA damage repair and cancer. Current projects include the INO80 remodelling complex, the Swr1 histone exchange complex and Tip60 acetylation/exchange complex. The successful applicants will join a multi-disciplinary team of scientists with varied expertise working on DNA repair processes from biochemistry to structural studies using both crystallography and electron microscopy.
The Staff Scientist position will require a person with extensive (5-8 years) post-doctoral experience of X-ray crystallography and/or single particle electron microscopy together with a sound knowledge of molecular biology/biochemistry. Post-doctoral candidates will have experience in either the biochemistry of protein:nucleic acid interactions or structural biology (electron microscopy or X-ray crystallography), preferably at a post-doctoral level.
The Division of Structural Biology has managed facilities for protein crystallography (Bruker Microstar with CCD detector, crystallisation robots), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression including a 60 L fermentor). The Division is also well equipped with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering).
The Staff Scientist will be appointed for 5 years in the first instance within the salary range £37477 to £44336 p.a. and the post-doctoral applicants will be appointed for 3 years initially within the scale £29695 to £37476 p.a.
Applications can be made to Prof. Dale Wigley (Dale.Wigley at icr.ac.uk).
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