From: Suzanne Zoe Fisher
Date: 2 May 2012 22:30
Dear Colleague,
The Protein Crystallography Station is a high performance neutron beamline located at the spallation neutron source at the Los Alamos Neutron Science Center in Los Alamos, NM. We are also pleased to announce that our in-house X-ray diffractometer is installed and available for user experiments as well. We also offer full support for perdeuterared protein expression, purification, and crystallization. The PCS routinely collects data on H/D exchanged samples and perdeuteration is not a requirement.
We are accepting proposals for our neutron beam run cycle starting 4th August and running until late December 2012.
We strongly encourage you to contact the instrument scientists for questions concerning sample preparation, instrument capabilities, sample environments, and/or proposal preparation:
PROPOSAL GUIDANCE AND SUBMISSION
Proposals may be submitted by clicking on the "Submit Proposal" link in the left column of the Lujan home page http://lansce.lanl.gov/lujan/index.shtml
When accessing the proposal submission site for the first time, use your e-mail address as the "Username" and click on the "forgot password" button. You will be sent a link by email to set your new password. After logging in, fill out or update your personal information. When you hit "save and continue", you will be directed to the first proposal submission page.
Check out the references below for exciting updates from our beamline:
- Chen et al. (2012) Room temperature ultra high resolution neutron and x-ray diffraction studies of H/D-exchanged crambin, Acta Crystallogr. D68, p.119-123.
- Fisher et al. (2011) Neutron structure of human carbonic anhydrase II: a hydrogen-bonded water network "switch" is observed between pH 7.8 and 10.0, Biochemistry 50, p.9421-9423.
- Kovalevsky et al. (2011) identification of the elusive hydronium ion (H3O+) exchanging roles with a proton in an enzyme at lower pH values, Angewandte Chemie 50, p.7520-7523.
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