We wish to recruit a Research Associate to work with Professor Xiaodong Zhang's research team in the Division of Molecular Biosciences, Centre for Structural Biology, at the South Kensington Campus of Imperial College London. This project is led by Prof. Xiaodong Zhang (http://www3.imperial.ac.uk/people/xiaodong.zhang) in collaboration with Prof. Dale Wigley, Institute of Cancer Research.
Eukaryotic genomic DNA is organized into nucleosomes and chromatin for genome stability and integrity. However, this creates barriers for processes that require access to the DNA, such as transcription and DNA repair. Chromatin remodeling complexes remodel nucleosomes and chromatin to provide access. The INO80 complex is a multi-subunit, large macromolecular machine that remodels nucleosomes upon DNA damage in order for the repair machinery to access the damaged DNA. We are currently conducting an exciting and comprehensive study on the structure and mechanism of the INO80 complex using a combination of protein biochemistry, X-ray crystallography and electron microscopy techniques. The successful candidate will join a team of scientists with diverse backgrounds and will be responsible for carrying out structural studies of the INO80 complex, primarily using electron microscopy techniques. The successful candidate will work closely with Prof. Wigley's laboratory at the Institute of Cancer Research, Chester Beatty Laboratories where the majority of the protein biochemistry will be carried out.
Successful candidates must hold a PhD in a structural biology or biochemistry discipline and have demonstrated an ability to carry out high quality original research using electron microscopy techniques.
Salary will be in the range of £31,300 – £33,020 per annum.
This position is funded for 3 years by the Wellcome Trust and is available from January 1 2012 onwards.
Closing date – November 10, 2011
Please apply online http://www3.imperial.ac.uk/employment/applicationforms/researcherapp
and quote reference NS 2011 187 KT
Professor Xiaodong Zhang
Imperial College London
Division of Molecular Biosciences
504, Wolfson laboratories
South Kensington, London, SW7 2AZ
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