From: Kevin Cowtan
Date: 19 September 2011 11:33
"Crystal structure of a monomeric retroviral protease solved by protein folding game players"
The paper (Nature SB):
http://www.cs.washington.edu/homes/zoran/NSMBfoldit-2011.pdf
The game:
http://fold.it/portal/
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From: Dirk Kostrewa
Great! Maybe, they should add an extra term for correlation of Fcalc to Fobs (or LLG or R) to their game. I wonder, if structures could be solved ab inition by players, then :-).
Best regards,
Dirk.
Am 19.09.11 12:33, schrieb Kevin Cowtan:
--
*******************************************************
Dirk Kostrewa
Gene Center Munich, A5.07
Department of Biochemistry
Ludwig-Maximilians-Universität München
Feodor-Lynen-Str. 25
D-81377 Munich
Germany
*******************************************************
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From: Nat Echols
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From: H. Raaijmakers
That's progress! A century ago we'd need an infinite amount of monkeys
typing on an infinite amount of typewriters to produce a single paper. Now
we need just a finite amount of gamers to produce 70000+ models to get one
that looks quite like a folded protein. And it saved an heavy atom soak as
well.
cheers,
Hans
ref. Émile Borel (1913). "Mécanique Statistique et Irréversibilité". J.
Phys. 5e série 3: 189–196.
Kevin Cowtan schreef:
Date: 19 September 2011 11:33
"Crystal structure of a monomeric retroviral protease solved by protein folding game players"
The paper (Nature SB):
http://www.cs.washington.edu/homes/zoran/NSMBfoldit-2011.pdf
The game:
http://fold.it/portal/
----------
From: Dirk Kostrewa
Great! Maybe, they should add an extra term for correlation of Fcalc to Fobs (or LLG or R) to their game. I wonder, if structures could be solved ab inition by players, then :-).
Best regards,
Dirk.
Am 19.09.11 12:33, schrieb Kevin Cowtan:
*******************************************************
Dirk Kostrewa
Gene Center Munich, A5.07
Department of Biochemistry
Ludwig-Maximilians-Universität München
Feodor-Lynen-Str. 25
D-81377 Munich
Germany
*******************************************************
----------
From: Nat Echols
Actually, Kam Zhang's group did something exactly like that by calling Phaser from Rosetta:
-Nat
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From: H. Raaijmakers
That's progress! A century ago we'd need an infinite amount of monkeys
typing on an infinite amount of typewriters to produce a single paper. Now
we need just a finite amount of gamers to produce 70000+ models to get one
that looks quite like a folded protein. And it saved an heavy atom soak as
well.
cheers,
Hans
ref. Émile Borel (1913). "Mécanique Statistique et Irréversibilité". J.
Phys. 5e série 3: 189–196.
Kevin Cowtan schreef:
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