Crystallographic and Physiologic but not Solution Oligomers

From: Jacob Keller


Dear Crystallographers,

does anyone have any nice examples/references of proteins which form
demonstrably physiologically-relevant oligomers in crystals, but which
do not appear to do so in solution? I am thinking particularly that
domains of membrane proteins which oligomerize primarily through their
TM domains would be subject to this, but all comers are certainly
welcome...

Jacob


----------
From: Jacob Keller


Thank you to everyone who responded to this query--here is a list of
proteins which oligomerize in crystals and in vivo, but not
appreciably in solution:

PknB--thanks to Christine Gee and Nat Echols
GluR ligand binding domains--thanks to Mark Mayer and Andrew Plested
Cadherins--thanks to Rachelle Gaudet
EGFR kinase--thanks to Markus Seeliger
FokI nuclease--thanks to Artem Evdokimov
NKR-P1 receptors--thanks to Jan Dohnalek
Insulin--thanks to Eleanor Dodson

All the best,

Jacob Keller