multi domain restriction for protein binding

From: Qiang Chen
Date: 16 December 2011 15:51



Hi guys,

I'm working on a multi-domain protein which uses three domains to form
homodimer, and the full-length structure is available. We have solved the
structure of one binding domain alone and found its homo-binding mode is
totally different from that within the context of the full-length protein.

I think the other domains may set some restrictions for the binding mode
of the one we've solved. Do you know examples or papers discussing the
similar subjects?

Thanks a lot!

Qiang