postdoc in oncology drug discovery

A recently funded project entitled "New Targets to Address Old Problems in Oncology" is recruiting personell. The goal of the project is to assess the feasibility of driving cancer cells into apoptosis by inhibiting transcription coupled repair (TCR) of DNA. The person will form part of a team of 3 working to develop small molecule inhibitors of the Cockayne Syndrome B (CSB) protein that initiates TCR. The project is a collaboration with the group of Prof. Leon Mullenders at the Leiden University Medical Center, while two companies ZoBio and Prestwick Chemicals, will provide support in the area of chemistry. My group will be responsible for the discovery and validation of small molecules that bind to and inhibit CSB. We will then use structural biology to enhance the potency of the CSB ligands. The group of Prof. Mullenders will develop in vitro and in vivo assays to determine the mode of action of the inhibitors and help to achieve the ultimate goal, that is to determine whether inhibition of CSB selectively drives cancer cells into apoptosis. We are currently seeking an an experienced, motivated post-Doc for three years with experience in X-ray crystallography.

To apply  please send a letter of motivation, your CV and the names and contact information of preferably 3 people willing to provide references g.siegal@chem.leidenuniv.nl.

--  Gregg Siegal Gorlaeus Laboratory  http://protchem.lic.leidenuniv.nl/