Date: 13 April 2012 19:14
The laboratory of Dr. Yoonsang Cho in the Department of Biochemistry
and Molecular Biology at Saint Louis University School of Medicine
invites a highly motivated and creative postdoctoral fellow who is
enthusiastic to study ligand-receptor systems involved in inflammatory
diseases and cancer. The successful candidate is expected to have
strong cell biology background and will be encouraged to mainly work
on a NIH-funded project to elucidate the molecular mechanisms of the
interaction between a chemokine-like protein and chemokine receptors
and its regulation by small molecules. The project will be highly
collaborative with medicinal chemists and immunologists for designing
and synthesizing new small molecules based on selected hits from high
throughput screening of small molecule libraries and evaluating their
therapeutic effects in animal models of human diseases. Depending on
the candidate's experience and interest, X-ray crystallography, NMR,
enzyme kinetics, and high throughput screening studies will be
conducted concomitantly.
The laboratory is located in the state of the art Doisy Research
Center (DRC) in the medical school. We have an innovative and powerful
label-free biosensor-based cellular assay system for the quantitative
measurement of cellular response in real time, an exclusive tissue
culture room, liquid chromatography purification system, and Macintosh
and Linux workstations. The department has three R-Axis IV++ imaging
plate systems for high-resolution X-ray diffraction data collection, a
crystallization robot, molecular graphics facility, differential
scanning calorimeter, isothermal titration calorimeter, dynamic light
scattering, metabolomics core facility, and bioinformatics facility.
In the same building, are animal care facility, flow cytometry
research core, animal imaging core, microarray core, research
microscopy and confocal core, and the Center for World Health and
Medicine, which provides a full range of support for drug discovery
programs including design and synthesis of small molecules and their
preclinical characterization.
Candidates must hold a Ph.D. in immunology, cell biology, biochemistry
or a related field. Solid knowledge and hands-on experience in
signaling studies with immune cells expressing cytokine/chemokine
receptors is essential. Structural and chemical biology experience is
a plus. He or she must have excellent skills in oral and written
English as well as inherent ability to organize experimental data for
efficient communication and publication.
Applicants should send a cover letter with their brief scientific
background and motivation for the position along with a complete CV,
including research experience and the names and contact information of
three references to Yoonsang Cho via email. Please feel free to make
informal inquiries via email.
No comments:
Post a Comment