Monday, 10 October 2011

Postdoc Position in Structural Biology of Microtubule Assembly



Postdoc Position in Structural Biology of Microtubule Assembly


The Knossow group at the Laboratoire d'Enzymologie et Biochimie Structurales in Gif-sur-Yvette (near Paris), France seeks to recruit a postdoctoral scientist in structural biology. The research focus is directed towards structures of complexes of tubulin with proteins that regulate its assembly in microtubules. For this purpose, we are also very active in the development of well defined tubulin assemblies amenable to crystallization. The results of some of these studies have been published (Ravelli et al. Nature 2004 ; Dorléans et al. PNAS 2009 ; Nawrotek et al. J. Mol. Biol. 2011) and other complexes are at the final stage of their development. Information about our group can also be obtained from http://www.lebs.cnrs-gif.fr/knossow/knossowang.html.

The position requires a Ph. D. in biochemistry or a related field with a strong background in molecular biology and protein biochemistry. Experience in purifying protein complexes and/or X-ray crystallography are an advantage. The successful candidate is a highly motivated individual who enjoys working as part of a collaborative, multidisciplinary and interactive team.

The laboratory, which is part of C.N.R.S., is excellently situated in the Molecular Biology environment of the Centre de Recherches de Gif in Gif-sur-Yvette. Access to synchrotron X-ray radiation (ESRF in Grenoble and SOLEIL, located nearby) and biophysical instrumentation (analytical ultracentrifugation, SEC - MALLS, Dynamic Light Scattering, microcalorimetry) is provided. The work will involve stays for limited periods of time in the Laboratory of Prof. A. Plückthun (U. Zürich) where the successful applicant will elicit DARPins specific of our proteins of interest (Zahnd et al. Nature Methods 2007).

The position is available immediately and funded initially for one year. The salary, determined according to the CNRS postdoc salary scale, is close to 2050 € per month for a candidate who has obtained his/her Ph.D. less than two years before starting this position.

To apply please send your CV, a statement of research interests and names (including Email addresses) of at least two referees to Dr. Marcel Knossow (knossow@lebs.cnrs-gif.fr). Applications will be accepted until the position is filled.


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