Date: 7 December 2011 10:22
Research Associate at Imperial College London
We are seeking to recruit a Research Associate to work with Professor Xiaodong Zhang's research team in the Division of Molecular Biosciences, Centre for Structural Biology, at the South Kensington Campus of Imperial College London (www.imperial.ac.uk/people/xiaodong.zhang).
In collaboration with Dr. Stephen West, Cancer Research UK, we are currently carrying out structural studies of BRCA2 and interacting partners. The successful candidate will work closely with Dr. Stephen West's laboratory at Cancer Research UK, where the majority of the protein production and biochemistry will be carried out. This position is funded for 3 years by the Medical Research Council and it is available from 1 March 2012.
Mutations in two breast cancer susceptibility genes, BRCA1 and BRCA2, have been linked to increased risk of developing cancers, especially breast and ovarian cancers. BRCA2 is one of the largest proteins in cells and only recently it has been successfully purified. The successful candidate will be responsible for carrying out structural studies of BRCA2 and associated complexes, primarily using electron microscopy techniques.
Applicants must hold a PhD or equivalent qualifications in a structural biology or biochemistry discipline. You must also have research experience in a structural biological laboratory environment covering electron microscopy single particle analysis or X-ray crystallography and knowledge to at least undergraduate level in protein biochemistry and structural biology. It is essential for the post holder to have the capacity for innovative high quality structural biological research. Knowledge of DNA damage repair is desirable.
The post holder must have excellent written and verbal communication skills, be able to conduct detailed reviews of literature, develop and apply new concepts well as rapidly learn new research methods. You must be able to demonstrate high levels of organisation and problem solving skills, the ability to pay close attention to detail, and to show initiative and innovation. It is also essential that you are able to organise your own work with minimal supervision ensuring you meet deadlines and research objectives. You must have experience in using advanced computer packages, especially electron microscopy image processing packages.
You must have discipline and regard for confidentiality and security at all times and be willing to work as member of a team and be open-minded and cooperative. A willingness to travel both within the United Kingdom and abroad to conduct research and attend conferences/workshops and other meetings is also essential.
Closing Date 9 January 2012 (midnight GMT)
How To Apply
Our preferred method of application is online via our website http://www3.imperial.ac.uk/employment (please select "Job Search" then enter the vacancy reference number including spaces NS 2011 233 KT into "Keywords"). Please complete and upload an application form as directed, attaching a curriculum vitae, a cover letter and the name and contact details of two referees. For informal enquiries please contact Professor Xiaodong Zhang xiaodong.zhang at imperial.ac.uk
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