Postdoctoral Position in Structural Biology at CCHMC

Applicants are invited to apply for a postdoctoral position in the area of structural biology and signal transduction. We are seeking one enthusiastic, well-trained and self-motivated scientist with excellent organizational and communication skills to join Dr. Nicolas Nassar's team at CCHMC. The research projects will focus on studying protein-protein and protein-small molecule interactions using X-ray crystallography, site-directed mutagenesis, fluorescence spectroscopy and other biophysical and cellular techniques.

One project in the lab focuses on understanding the cycling of Ras and other small GTP-binding proteins between the active and inactive forms and finding ways to inhibit their signaling in disease. Another area of research focuses on the Sts family (Sts-1/-2) of phosphatases. These are multidomain proteins that negatively regulate T cell receptor (TCR) signaling and other membrane receptors, including EGFR. We are interested in understanding the mechanism behind dephosphorylation of  pTyr-containing proteins and the nature of the Sts substrates.

Applicants must have extensive experience in molecular biology, recombinant protein purification, fluorescence spectroscopy or a related biophysical or biochemical technique. Experience in studying biochemical, cellular and structural aspects of signal transduction would be particularly desirable but other applicants with relevant experience will also be considered.

Cincinnati Children's Hospital Medical Center is an internationally renowned institute. Research at The Division of Experimental Hematology and Cancer Biology is in the areas of experimental hematology, cancer, and gene therapy. The division's goals are to understand the biology of blood cell formation and function and to dissect cancer etiology and pathology so that the knowledge can be used in the development of innovative treatments of genetic and acquired diseases affecting the blood system and cancer. Research efforts are allocated in six basic research programs within the division to optimize the potential for translational research in children with genetic blood diseases, immunodeficiencies, cancers, and leukemia. We provide a stimulating and supportive environment and our expertise covers a range of experimental systems.

(http://www.cincinnatichildrens.org/research/div/exp-hematology/default.htm)

Send CV, cover letter and a list of references to nicolas.nassar at cchmc.org