From: Bussiere, Dirksen
Date: 22 February 2012 01:38
Colleagues:
This is a bit off-topic, but there are two positions available in our group for scientists with experience in biophysics and SPR. The description of each position follows as does application instructions. The first position listed is for an experienced Ph.D.-level scientist; the second position for an experienced B.S./M.S.-level scientist.
Novartis Institutes for BioMedical Research
SPR / Solution Biophysics Scientist - Inv III / Sr Inv I, Structural Chemistry
Requisition No. 93406BR
NIBR - Novartis Institutes for BioMedical Research
Emeryville, CA
About Novartis Institute of Biomedical Research
At Novartis Institutes for BioMedical Research ("NIBR"), the global research organization of Novartis, we are committed to discovering innovative medicines to cure disease and improve human health. By hiring the best academic, biotech, and pharmaceutical trained scientists, we have fostered an atmosphere for drug discovery where innovation is rewarded. It is ultimately the talent of the individual that determines our success, while our state-of-the-art technologies and resources enable these ideas to be realized.
NIBR has sites in Cambridge, Massachusetts; Emeryville, CA; Basel, Switzerland; Horsham, UK; and Shanghai, China. Our Emeryville location focuses on early drug discovery efforts for the Oncology Disease Area and offers a variety of positions in Biology, Chemistry, and functions such as Technology, Patents, Research Sciences and other areas that support our scientific resources.
About Structural Chemistry
The NIBR Emeryville Structural Chemistry group is responsible for actively pursuing protein-ligand interaction studies using NMR spectroscopy, X-ray crystallography, and complementary biophysical methods to support drug discovery projects. The group also determines the structures of macromolecular drug targets either as apo-proteins or in complex with lead compounds to help guide structure-based drug design, and actively participates in the drug discovery process.
We are seeking a multifaceted individual with a strong scientific background and relevant expertise in the use of surface plasmon resonance (SPR) and other biophysical methods, such as isothermal calorimetry, to discover small molecule inhibitors and activators of drug targets, particularly in the context of fragment-based lead discovery.
Responsibilities:
· Design, develop, and implement SPR and other biophysical assays suitable for hit identification and validation as part of ongoing fragment-based screening efforts.
· Drive the implementation of new technological approaches and capabilities in regards to solution biophysics.
· Create and implement project plans, and coordinate workflow and logistics to meet project goals and milestones.
· Participate on multidisciplinary teams to evaluate new leads and to validate new targets.
Qualifications:
· Ph.D. in Biochemistry, Biophysics, or other relevant field, with 3-10 years of relevant postgraduate experience, including biotechnology and/or pharmaceutical industry experience.
· In-depth knowledge of biophysics is required, and experience with SPR technology and its application in fragment-based screen are essential. Experience with biophysics assay technologies such as fluorescence-based techniques (FP, FRET), calorimetry (ITC, DSC), light scattering (StarGazer) are highly desirable.
· Experience in structure-based drug design and the optimization of ligand-efficient fragments would be a plus.
· Experience with laboratory instrumentation and automation, data analysis and management, and a sound knowledge of the drug discovery process is also highly desirable.
· Some knowledge of current infectious disease and oncology research is a plus.
· Ability to devise experimental strategies and execute them in a timely manner to produce goal-oriented results is essential.
· Ability to work with Novartis scientists from multiple disciplines is required and exceptional written, verbal, and team skills are essential.
· Demonstrated solid track record of scientific achievements is required.
To apply for this position, please visit www.novartis.com, click on the Careers link, pull the menu down to Job Search, and search for job ID 93406BR.
Solution Biophysics Research Associate – Scientist II
Requisition No. 93761BR
NIBR - Novartis Institutes for BioMedical Research
Emeryville, CA
Responsibilities:
· Working with PhD-level scientists to develop and implement SPR and other biophysical assays suitable for hit identification and validation as part of ongoing fragment-based screening efforts.
· Implement project plans, and coordinate workflow and logistics to meet project goals and milestones.
· Participate on multidisciplinary teams to evaluate new leads and to validate new targets.
Qualifications:
· B.A. or M.S. in Biochemistry, Biophysics, or other relevant field, with 3-10 years of relevant work experience; biotechnology and/or pharmaceutical industry experience would be helpful
· Experience with SPR technology and its application in fragment-based screen are essential. Experience with biophysics assay technologies such as fluorescence-based techniques (FP, FRET), calorimetry (ITC, DSC), light scattering (StarGazer) are highly desirable.
· Experience in structure-based drug design and the optimization of ligand-efficient fragments would be a plus.
· Experience with laboratory instrumentation and automation, data analysis and management is also highly desirable.
· Ability to work with Novartis scientists from multiple disciplines is required and exceptional written, verbal, and team skills are essential.
To apply for this position, please visit www.novartis.com, click on the Careers link, pull the menu down to Job Search, and search for job ID 93761BR.
Dirksen Bussiere
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