real dimer vs crystal packing

From: Qiang Chen
Date: 12 January 2012 16:03


Hi,

I'm working on a multi-domain protein which uses three domains to form
homodimer, and the full-length structure is available. We have solved the
structure of one binding domain alone and found its homo-binding mode is
totally different from that of the full-length protein.

Do you know examples or papers discussing the similar subjects (crystal
packing shows false binding mode)?

Thanks a lot!

Qiang



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From: Artem Evdokimov

PDE2 full length versus domain only structures, I think.

Artem