From: Chris Ulens
Date: 7 February 2012 09:16
Dear colleagues,
I am looking for a few example studies in which a complete mutagenesis of all residue-ligand interactions has been conducted to evaluate the energetic contributions of each individual interaction.
Thank you.
Best regards.
-Chris
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Chris Ulens, Ph.D.
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From: Savvas Savvides
Dear Chris
A whole series of studies from the early to late 90's did his for the growth hormone-GHR interaction.
Papers by Pearce, Cunningham, Clackson and Wells come to mind.
Also a recent study on the IL13-IL13R interaction by Lupardus et al has covered most of the interaction epitope.
Best regards
Savvas
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