The position is available in the laboratory of Aitor Hierro to work in the area of structural
biology and membrane trafficking.
We study the interactions, in molecular mechanistic detail, that underlie the selectivity of
cargo transport vesicles for recognizing the correct target membrane. We do this using a
combination of structural, biochemical and biophysical approaches. The focus of the project
is on a series of soluble and membrane associated proteins (and their complexes), which
coordinate tethering and fusion of transport vesicles from endosomes to the Golgi apparatus
(for references, see PMDIs: 20615984; 21183348 and 17891154).
The position requires PhD. degree with a strong background in molecular biology for
heterologous recombinant protein expression in different hosts such Escherichia coli, insect
cell-baculovirus and mammalian cells. Previous experience in X-ray crystallography and the
use of biophysical or biochemical techniques for the characterization of protein complexes
would be an advantage.
Local resources at the institute include shared state-of-the-art facilities for high throughput
crystallization, and in-house X-ray data collection. We also have regular synchrotron
beamtime. Other biophysical instrumentation such DLS, ITC, DSC, CD, SEC-MALLS
and fluorescence spectrometers are also available. For testing our structural and in vitro
analyses we have complementary collaborations with leading laboratories in the cell biology
field. The institute is well-situated with numerous groups working in X-ray crystallography,
NMR and EM that form a critical mass in the area of structural biology. This position offers an
excellent opportunity for an experienced protein biochemist/biophysicist or cell biologist to
complement his or her expertise in X-ray crystallography working at the juncture between
structural biology and cell biology.
The position is available beginning December 2011 and funded for 3+2 years. Applications
will be accepted until the position is filled.
Interested candidates please email a cover letter, your CV, and names (including email
address) of at least two referees to rrhh@cicbiogune.es with ref. 3131 in the subject.
biology and membrane trafficking.
We study the interactions, in molecular mechanistic detail, that underlie the selectivity of
cargo transport vesicles for recognizing the correct target membrane. We do this using a
combination of structural, biochemical and biophysical approaches. The focus of the project
is on a series of soluble and membrane associated proteins (and their complexes), which
coordinate tethering and fusion of transport vesicles from endosomes to the Golgi apparatus
(for references, see PMDIs: 20615984; 21183348 and 17891154).
The position requires PhD. degree with a strong background in molecular biology for
heterologous recombinant protein expression in different hosts such Escherichia coli, insect
cell-baculovirus and mammalian cells. Previous experience in X-ray crystallography and the
use of biophysical or biochemical techniques for the characterization of protein complexes
would be an advantage.
Local resources at the institute include shared state-of-the-art facilities for high throughput
crystallization, and in-house X-ray data collection. We also have regular synchrotron
beamtime. Other biophysical instrumentation such DLS, ITC, DSC, CD, SEC-MALLS
and fluorescence spectrometers are also available. For testing our structural and in vitro
analyses we have complementary collaborations with leading laboratories in the cell biology
field. The institute is well-situated with numerous groups working in X-ray crystallography,
NMR and EM that form a critical mass in the area of structural biology. This position offers an
excellent opportunity for an experienced protein biochemist/biophysicist or cell biologist to
complement his or her expertise in X-ray crystallography working at the juncture between
structural biology and cell biology.
The position is available beginning December 2011 and funded for 3+2 years. Applications
will be accepted until the position is filled.
Interested candidates please email a cover letter, your CV, and names (including email
address) of at least two referees to rrhh@cicbiogune.es with ref. 3131 in the subject.
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