Friday 9 September 2011

Workshop on Dynamic X-ray Scattering in Structural Biology 2011

From: Vukica Srajer
Date: 5 September 2011 13:13

Second Announcement – Registration is now open at

http://cars9.uchicago.edu/biocars/pages/DXSworkshop11/index.shtml

Workshop on Dynamic X-ray Scattering in Structural Biology 2011
November 2 - 4, 2011
Hosted by BioCARS, The University of Chicago
Held at Advanced Photon Source, Argonne National Laboratory

Organized by Zhong Ren,renz@uchicago.edu, 630-252-0498
Administrative contact: Katie Tietz,tietz@cars.uchicago.edu, 630-252-0450

This workshop will provide hands-on training in designing and conducting time-resolved experiments principally in macromolecular crystallography, but also in fiber diffraction and solution scattering from biological samples. BioCARS and BioCAT users will learn about the exciting capabilities in dynamic scattering at beamlines 14-ID and 18-ID of the APS.

The workshop will feature three Lecture Sessions. The first will focus on the experimental techniques of time-resolved crystallography using either Laue or monochromatic diffraction. The second concerns a notable challenge of dynamic crystallography lying in data analysis and structure refinement. The third will showcase recent examples of structural dynamics that go beyond classical time-resolved crystallography. Four hands-on sessions (Crystallization, Experiment, Software and Case Study) are designed to offer an overview of various experimental approaches to capturing dynamic structures. In the Crystallization Session, we will demonstrate novel crystallization techniques for room temperature diffraction, often a key requirement for dynamic crystallography. The Software Session will provide training on data analysis and structure refinement of time-dependent structural changes. In the Experiment Session, attendees are invited to bring their own crystal samples and to conduct preliminary testing of their diffraction quality, often the first step in developing time-resolved projects. After the participants have familiarized themselves with a variety of theoretical and practical aspects of time-resolved experiments, we encourage attendees to present their specific cases in structural biology and prospective projects in the Case Study Session. Through one-on-one discussions with BioCARS and BioCAT staff or in a group discussion, this session will provide an opportunity to identify promising experimental approaches, potential difficulties and feasible solutions to the participants' specific problems.

Please note that due to time limitation, hands-on sessions will be able to accommodate up to 25 participants for the BioCARS experiment and software sessions and up to 10 participants for the BioCAT experiment session. Lecture sessions are open to all registered participants.

Please send questions and comments to Zhong Ren (renz@uchicago.edu) or Katie Tietz (tietz@cars.uchicago.edu).

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Vukica Srajer Ph.D.
University of Chicago/CARS
9700 South Cass Ave, Bldg 434B
Argonne, IL 60439
tel: (630) 252-0455
fax: (630) 252-0443
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