-Dirk
Protein Crystallographer/Biophysicist – Investigator III, Req # 89655BR
Novartis Institutes of BioMedical Research
Emeryville, CA
About Novartis Institute for Biomedical Research:
At Novartis Institutes for BioMedical Research (NIBR), the global research organization of Novartis, we are committed to discovering innovative medicines to cure disease and improve human health. By hiring the best academic, biotech, and pharmaceutical trained scientists, we have fostered an atmosphere for drug discovery where innovation is rewarded. It is ultimately the talent of the individual that determines our success, while our state-of-the-art technologies and resources enable these ideas to be realized.
NIBR has sites in Cambridge, Massachusetts; Emeryville, CA; Basel, Switzerland; Horsham, UK; and Shanghai, China. Our Emeryville location focuses on early drug discovery efforts for the Oncology and Infectious Disease Areas and offers a variety of positions in Biology, Chemistry, and functions such as Technology, Patents, Research Sciences and other areas that support our scientific resources.
About Structural Chemistry:
The NIBR Emeryville Structural Chemistry group is responsible for actively pursuing the structures of macromolecular drug targets either as apo-proteins or in complex with lead compounds to help guide structure-based drug design, and actively participates in the drug discovery process. The group also provides biophysics and solutions studies support for drug discovery projects.
Position Description:
The qualified candidate will use his/her scientific expertise to aid in structure-based drug design efforts. Specifically, this individual will determine high-resolution, three-dimensional structures of macromolecular drug targets (typically proteins), including crystallization and structure solution of medically important structures and target-ligand complexes. This individual will interact with computational chemists and medicinal chemists to design new scaffolds and improve lead compounds. Additionally, this individual will provide biophysical support for fragment based drug discovery efforts and other biophysical studies.
Qualifications: The ideal candidate will have -
· An M.S. degree and 7 or more years of work experience or a Ph.D. and 3-6 years of postdoctoral and/or work experience. Degrees in Biochemistry, Chemistry, or Molecular Biophysics are acceptable.
· Strong experience in protein biochemistry, protein crystallization, crystallographic methods, structure solution, structure refinement and molecular modeling. Pharmaceutical industry experience is a plus.
· Significant experience in the use of biophysics (SPR, ITC, DSC, etc.) to support biological research and drug discovery projects. Experience in supporting fragment-based drug discovery is a plus.
· Excellent verbal and written communication skills and the ability to work in large, multidisciplinary project teams.
If you are interested in applying to this position then please follow these instructions.
1) Go to the following web page (this is the careers page on the Novartis web-site).
http://www.novartis.com/careers/job-search/index.shtml
2) Enter the following job code into the search box: 89655BR
A live link to the job will appear below the search box.
3) Click on the link and you will then be brought to the job description where you can apply online.
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